ea0063p709 | Pituitary and Neuroendocrinology 2 | ECE2019
Cano David
, Garcia-Martinez Araceli
, Flores Alvaro
, Gil Joan
, Puig-Domingo Manel
, Webb Susan M
, Soto Alfonso
, Pico Antonio
Introduction: Previous results of our group, presented in the ECE last year, showed a lower gene expression of proconvertase PC1/3, involved in the processing of POMC, in silent corticotroph tumors (sCT) than in functioning ones (fCT), overall and in microadenomas. The aim of the present study was to quantify the protein expression of convertases involved in the processing of POMC (PC1/3) and in the degradation of ACTH (PC2, CPE and PAM) in a series of CT.</p...